Ver el código de «Ondansetron»

==General==
*Type: anti-emetic
*Dosage Forms:4, 8
*Common Trade Names: Zofran

==Adult Dosing==
*Nausea/Vomiting: 4-8mg q4h, max 24mg a day
==Pediatric Dosing==
*Nausea/Vomiting: 0.1mg/kg IV q4h max dose at once:4-8mg, max 24mg
*Gastroenteritis - Vomiting
**8 to 15 kg: 
***2mg orally disintegrating tablet dissolved orally as a single dose  
**15 to 30 kg: 
***4mg orally disintegrating tablet dissolved orally as a single dose 
**Greater than 30 kg: 
***8mg orally disintegrating tablet dissolved orally as a single dose

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C 
**Consider avoiding in 1st trimester; conflicting data regarding possible risk of teratogenicity
**Newer data argues that ondansetron is not the cause of birth defects<ref>Fejzo MS, et al. Ondansetron in pregnancy and risk of adverse fetal outcomes in the United States. Reprod Toxicol. 2016 Jul;62:87-91.</ref>
*Lactation:safety unknown
*Renal Dosing: 
**Adult: not defined
**Pediatric: not defined
*Hepatic Dosing: not defined
**Adult: not defined
**Pediatric: not defined

==Contraindications==
*Allergy to class/drug
*Congenital long QT syndrome
*Serotonin syndrome

==Adverse Reactions==
===Serious===
*bronchospasm
*steven-johnson syndrome
*QT prolongation
*torsades de pointes
*serotonin syndrome
*extrapyramidal SX
*blindness, transient
===Common===
*headache
*constipation
*fatigue
*hypoxia
*fever
*urinary retention
*agitation
==Pharmacology==
*Half-life: 4.6-5.7 hour
*Metabolism: liver
*Excretion: urine
*Mechanism of Action:selectively antagonizes serotonin 5-HT3 receptors

==See Also==


==References==
<references/>

[[Category:Pharmacology]]