Ver el código de «Metronidazole»

==General==
*Type: Other Antibacterials
*Dosage Forms: 
**IV
**PO: 250mg; 375mg; 500mg
*Common Trade Names: Flagyl

==Adult Dosing==
===General===
*'''PO'''
**500 mg PO q6-8h x 7-10 days
**First Dose: 500 mg PO x 1
*'''IV'''
**15mg/kg IV x1, then 7.5mg/kg IV q6h
**First Dose: 15mg/kg IV x1
*Max: 1 gram/dose

==Pediatric Dosing==
===General (<1200g)===
*7.5 mg/kg PO/IV q48h
*First Dose: 7.5 mg/kg PO/IV x 1

===General (>1200g AND <1 Month Old)===
*'''<7 days old'''
**7.5-15 mg/kg/day PO/IV q12-24h
**First Dose: 7.5-15 mg/kg PO/IV x 1
*'''>7 days old'''
**15-30 mg/kg/day PO/IV q12h
**First Dose: 7.5-15 mg/kg PO/IV x 1

===General (>1 Month Old)===
*30 mg/kg/day PO/IV q6h
*First Dose: 7.5 mg/kg PO/IV x 1
*Max: 4 g/day

==Special Populations==
*Pregnancy: B
*Lactation: Safety conditional
*Renal Dosing
**Adult
**Pediatric
*Hepatic Dosing
**Adult
**Pediatric

==Contraindications==
*Black Box: carcinogenic in mice and rats; avoid unnecessary use; reserved for approved conditions
*Allergy to class/drug
*Pregnancy (single 2 dose retimen)
*Alcohol use within 3 days
*Disulfram use within 14 days

==Adverse Reactions==
===Serious===
*[[Seizures]]
*Aseptic [[meningitis]]
*Perifpheral neuropathy
*Optic neuropathy
*Encephalopathy
*[[Hypersensitivity Reaction]]
*[[Stevens-Johnson Syndrome]]
*[[Toxic Epidermal Necrolysis]]
*Leukopenia
*Carcinogenicity (in animals)

===Common===
*[[Nausea and Vomiting]]
*Epigastric discomfort
*[[Diarrhea]]
*Metallic taste
*[[Rash]]
*[[Headache]]
*[[Dizziness]]
*Dark reddish-brown urine
*Candidiasis
*Thrombophlebitis (IV use)

==Pharmacology==
*Half-life: 8h
*Metabolism: Liver; CYP450: 2C9 inhibitor
*Excretion: Urine (70%); feces (15%)
*Mechanism of Action: Bactericidal

==See Also==
*[[Antibiotics (Main)]]

==Source==
*Epocrates

[[Category:Drugs]]