Ver el código de «Amitriptyline»

==Administration==
*Type: [[Tricyclic antidepressant]]
*Dosage Forms: tablet, injectable solution
*Routes of Administration: PO, IM
*Common Trade Names: Elavil, Levate

==Adult Dosing==
*50-100-300mg daily, in 1-3 doses

==Pediatric Dosing==
''Safety/efficacy not established in children <12yo''
*>12yo: 10mg TID and 20mg qHS

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
*[[Lactation risk categories|Lactation risk]]: Infant risk cannot be ruled out
*Renal dosing:
*Hepatic dosing: use with caution

==Contraindications==
*Allergy to class/drug
*Use of MAOIs concomitantly or within 14 days
*Recent MI
*Concomitant use of cisapride

==Adverse Reactions==
===Serious===
*Prolonged QT, dysrhythmia, MI, sudden cardiac death
*Agranulocytosis
*Hepatotoxicity
*Neuroleptic malignant syndrome
*Seizure
*Worsening depression, suicidality
===Common===
*Somnolence, dizziness
*Headache
*Constipation, xerostomia
*Blurred vision
*Weight gain

==Pharmacology==
*Half-life: 9 - 27 hours
*Metabolism: Hepatic via CYP2D6
*Excretion: Urine, small amounts in feces

==Mechanism of Action==
Neurotransmitter (especially norepinephrine and serotonin) reuptake inhibitor; anticholinergic

==Comments==

==See Also==
*[[TCA toxicity]]

==References==
<references/>
[[Category:Pharmacology]]