Ver el código de «Acute myeloid leukemia»

==Background==
*AKA Acute myelogenous leukemia or non-lymphocytic leukemia 
*Most common acute leukemia in adults (around 80% of cases) 
*65 yo median age of diagnosis, Male:Female 5:3 
*Characterized by clonal proliferation of myeloid precursors(blast cells >20% in the periphery)

==Clinical Features==
*Presents with anemia, neutropenia, thrombocytopenia, 
*Weakness, easy fatigability, infections, gingival bleeding/enlargement, ecchymoses, epistaxis, menorrhagia

==Differential Diagnosis==
{{Leuk/lymph DDX}}

==Evaluation==
*[[CXR]] 
*CBC with peripheral smear 
*Chem7, ca, mg, phos, Uric Acid, UA, LDH (to check for Tumor Lysis) 
*LFTs, Coags, FDP, D-Dimer, Haptoglobin, Fibrinogen (to check for DIC) 
*ESR, CRP
*Reticulocyte count in anemia
*Get extra purple top for flow cytometry, especially before transfusion

==Treatment==
*Aggressive IV hydration 
*If febrile, complete cultures and broad spectrum antibiotics 
*Manage Complications 
**See [[DIC]] 
**See [[Leukostasis]] 
**See [[Hyperviscosity syndrome]]
**See [[Tumor Lysis Syndrome]]
**See [[Retinoic acid syndrome]]

==See Also==
*[[Oncologic emergencies]]
*[[Acute leukemia]]

==References==
*Janz TG, Hamilton GC: Anemia, Polycythemia and White Blood Cell Disorders, in Marx JA, Hockberger RS, Walls RM, et al (eds): Rosen’s Emergency Medicine: Concepts and Clinical Practice, ed 8. St. Louis, Mosby, Inc., 2014, (Ch) 121:p 1586-1605.
[[Category:Heme/Onc]]