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==General==
*Type: First generation [[cephalosporin]]
*Dosage Forms: 500, 1000; 250, 500/5ml susp
*Common Trade Names: Duricef

==Adult Dosing==
===Infections, bacteria===
*1-2g/day PO divided q12-24h

===[[Pharyngitis]]/tonsillitis, [[streptococcal]]===
*1g PO divided q12-24h x 10days

==Pediatric Dosing==
*infections, bacterial
**30mg/kg/day PO divided q12-24h max 2g/day

*paryngitis/tonsillitis, streptococcal
**30mg/kg/day PO divided q12-24h x 10days, max 1g/day

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: B (no evidence of harm)
*Lactation: safe (no risk/minimal risk)
*Renal Dosing
**Adult
***GFR 25-50: 1g x1, then 500mg q12h
***GFR 10-25: 1g x1 then 500mg q24h
***GFR < 10: 1g x1, then 500mg q36h
***HD: give 0.5-1g supplement
***PD: 500mg q24h
**Pediatric
***GFR 10-25: give q24h
***GFR < 10: give q36h
***HD: give supplement
***PD: no supplement
*Hepatic Dosing
**Adult: not defined
**Pediatric: not defined

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
===Serious===
*anaphylaxis
*Stevens-Johnson syndrome
*toxic epidermal necrolysis
*angioedema
*neutropenia
*thrombocytopenia
*pancytopenia
*anemia, hemolytic
*aplastic anemia
*hemorrhage
*seizures
*superinfection
*C.difficile-associated diarrhea

===Common===
*diarrhea
*nausea
*dyspepsia
*urticaria
*pruritus
*rash
*vomiting
*ALT, AST elevation

==Pharmacology==
*Half-life: 
**78-96 min, 20-25hr (ESRD)
*Metabolism: 
**minimal, site unknown
*Excretion: 
**urine primarily (>90% unchanged)
*Mechanism of Action:
**bacteriacidal; inhibits cell wall mucopeptide synthesis

==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy 2014</ref>==
{| class="wikitable"
| align="center" style="background:#f0f0f0;"|'''Group'''
| align="center" style="background:#f0f0f0;"|'''Organism'''
| align="center" style="background:#f0f0f0;"|'''Sensitivity'''
|-
| Gram Positive||[[Strep. Group A, B, C, G]]||'''S'''
|-
| ||[[Strep. Pneumoniae]]||'''S'''
|-
| ||[[Viridans strep]]||'''S'''
|-
| ||Strep. anginosus gp||X1
|-
| ||[[Enterococcus faecalis]]||R
|-
| ||[[Enterococcus faecium]]||X1
|-
| ||[[MSSA]]||'''S'''
|-
| ||[[MRSA]]||R
|-
| ||[[CA-MRSA]]||R
|-
| ||[[Staph. Epidermidis]]||I
|-
| ||[[C. jeikeium]]||R
|-
| ||[[L. monocytogenes]]||R
|-
| Gram Negatives||[[N. gonorrhoeae]]||R
|-
| ||[[N. meningitidis]]||R
|-
| ||[[Moraxella catarrhalis]]||R
|-
| ||[[H. influenzae]]||X1
|-
| ||[[E. coli]]||'''S'''
|-
| ||[[Klebsiella]] sp||'''S'''
|-
| ||E. coli/Klebsiella ESBL+||R
|-
| ||E coli/Klebsiella KPC+||R
|-
| ||[[Enterobacter]] sp, AmpC neg||R
|-
| ||[[Enterobacter]] sp, AmpC pos||R
|-
| ||[[Serratia]] sp||R
|-
| ||Serratia marcescens||X1
|-
| ||[[Salmonella]] sp||R
|-
| ||[[Shigella]] sp||R
|-
| ||[[Proteus mirabilis]]||'''S'''
|-
| ||[[Proteus vulgaris]]||R
|-
| ||[[Providencia sp.]]||R
|-
| ||[[Morganella sp.]]||R
|-
| ||[[Citrobacter freundii]]||R
|-
| ||[[Citrobacter diversus]]||R
|-
| ||[[Citrobacter sp.]]||X1
|-
| ||[[Aeromonas sp]]||X1
|-
| ||[[Acinetobacter sp.]]||R
|-
| ||[[Pseudomonas aeruginosa]]||R
|-
| ||[[Burkholderia cepacia]]||R
|-
| ||[[Stenotrophomonas maltophilia]]||R
|-
| ||[[Yersinia enterocolitica]]||X1
|-
| ||[[Francisella tularensis]]||X1
|-
| ||[[Brucella sp.]]||X1
|-
| ||[[Legionella sp.]]||R
|-
| ||[[Pasteurella multocida]]||X1
|-
| ||[[Haemophilus ducreyi]]||X1
|-
| ||[[Vibrio vulnificus]]||X1
|-
| Misc||[[Chlamydophila sp]]||X1
|-
| ||[[Mycoplasm pneumoniae]]||X1
|-
| ||[[Rickettsia sp]]||X1
|-
| ||[[Mycobacterium avium]]||X1
|-
| Anaerobes||[[Actinomyces]]||X1
|-
| ||[[Bacteroides fragilis]]||X1
|-
| ||[[Prevotella melaninogenica]]||X1
|-
| ||[[Clostridium difficile]]||X1
|-
| ||[[Clostridium (not difficile)]]||X1
|-
| ||[[Fusobacterium necrophorum]]||X1
|-
| ||[[Peptostreptococcus sp.]]||X1
|}

===Key===
{{Template:Antibacterial Spectra Key}}
==See Also==
*[[Antibiotics (Main)]]

==References==
<references/>

[[Category:Pharmacology]]