Ver el código de «EDTA»

==Administration==
*Type: [[Antidote]] (chelator)
*Dosage Forms:
*Routes of Administration: IV/IM
*Alternate names: Calcium Disodium Edathamil, Calcium Disodium Edetate, ethylenediamine tetraacetic acid, Edetic acid, Edetate calcium

==Adult Dosing==
*Asymptomatic or symptomatic lead poisoning, level 20-70 mcg/dL: 1000 mg/m(2)/day IV over 8-12h OR IM in divided doses q8-12 hours
*Administer with [[dimercaprol]] if level >70 mcg/dL or symptomatic
==Pediatric Dosing==
*Same as above

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: B
*[[Lactation risk categories|Lactation risk]]: Infant risk cannot be ruled out
*Renal dosing: reduce dose if mild impairment, contraindicated if anuria or active renal disease
*Hepatic dosing: contraindicated in active hepatitis

==Contraindications==
*Allergy to class/drug
*Anuria, active renal disease
*Active hepatitis

==Adverse Reactions==
===Serious===
''All listed here are relatively frequent complications''
*Hypotension
*Thrombophlebitis
*Fever
*Nephrotoxicity
*Hypersensitivity reaction
===Common===
*Injection site pain
*Nausea/vomiting
*Myalgia
*Headache

==Pharmacology==
*Half-life: 20-60min
*Metabolism: Not metabolized
*Excretion: Renal

==Mechanism of Action==
*Divalent/trivalent metals (especially lead) replace calcium in EDTA forming stable, soluble complexes that are readily excreted

==Comments==

==See Also==
*[[Antidotes]]
*[[Lead toxicity]]
*[[Dimercaprol]]
==References==
<references/>
[[Category:Pharmacology]]